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Table 4 Disease characterization of coexpression modules in each network

From: Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls

Control Network

Module Theme

Module No.

Module Size

SZUP Overlap

SZDOWN Overlap

   

(25 genes)

(73 genes)

Oxidative phosphorylation

CTL24

1996

0

34***

Glutamine metabolism

CTL20

504

7***

0

Myelination

CTL25

749

2

0

Immune response

CTL1

329

3**

0

Synaptic transmission

CTL18

291

0

10***

Schizophrenia Network

Module Theme

Module No.

Module Size

SZUP Overlap

SZDOWN Overlap

   

(25 genes)

(73 genes)

Oxidative phosphorylation

SZ3

1144

0

34***

Glutamine metabolism

SZ9

717

12***

1

Myelination

SZ20

711

2

0

Immune response

SZ15

198

0

0

Ubiquitination

SZ2

1424

0

12

  1. The top five modules in each network were characterized by enrichment of genes that are differentially expressed in schizophrenia. Module themes were assigned based on Gene Ontology enrichment analysis. Disease effect p-values were computed by entering the t-statistic for the disease effect of each gene into a Wilcoxon rank-sum test by module. For all modules listed the disease effect p-values are p < << 0.001 and values can be found in the supplement. SZUP and SZDOWN are the up- and down-regulated schizophrenia gene sets previously identified in our meta-analysis [2]. **p < 0.01; ***p < < 0.001.