Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls

Table 5 Cell-type marker enrichment of coexpression modules in each network

Control Network
		Low stringency threshold ( > 4-fold)
Module Theme	Module No.	Oligodendrocyte	Neuron	Astrocyte
Oxidative phosphorylation	CTL24	43	253***	48
Glutamine metabolism	CTL20	23*	9	166***
Myelination	CTL25	115***	16	42
Immune-related	CTL1	7	10	44***
Synaptic transmission	CTL18	7	85***	9
Schizophrenia Network
		Low stringency threshold ( > 4-fold)
Module Theme	Module No.	Oligodendrocyte	Neuron	Astrocyte
Oxidative phosphorylation	SZ3	23	181***	22
Glutamine metabolism	SZ9	41***	20	203***
Myelination	SZ20	109***	16	28
Immune-related	SZ15	3	4	11
Ubiquitination	SZ2	34	157***	36

For the top disease-associated clusters in each network we report the number of genes that overlap with published lists of cell-type marker genes for oligodendrocytes , neurons, and astrocyte marker genes provided by [15]. Cell-type enrichment for all modules in each network and results for high stringency lists (> 10-fold) can be found in Additional file 4: Table 1. Hypergeometric probabilities were computed to evaluate significance of overlap. *p < 0.05; ***p < < 0.001.

ISSN: 1471-2202