ETNA nomenclature | E8 | E5 | hQC |
|---|
E5 | wt | - | wt | - |
E5 | het | - | het | - |
E5 | hom | - | hom | - |
E8 | wt | wt | - | - |
E8 | het | het | - | - |
E8 | hom | hom | - | - |
E85 | wt/wt | wt | wt | - |
E85 | het/het | het | het | - |
E8-hQC | wt/wt | wt | - | wt |
E8-hQC | hom/wt | hom | - | wt |
E8-hQC | hom/het | hom | - | het |
E8-hQC | hom/hom | hom | - | hom |
E85-hQC | het/het/wt | het | het | wt |
E85-hQC | het/het/hom | het | het | hom |
- Overview of used genotypes and nomenclature of ETNA models. Wildtype (wt), heterozygous (het), and homozygous (hom) animals of single transgenic E5 and E8 models were used.
- For the double transgenic E85 model, the E8 and E5 models were crossbred and only double heterozygous (het/het) and wildtype (wt/wt) animals were used.
- E8 and E85 animals were intercrossed with hQC animals to generate multi-tg ETNA-hQC animals. In these models the genotype of the hQC allele is always indicated last.
- For the double transgenic E8-hQC model, In E8-hQC the E8 allele was always homozygous in hom/wt, hom/het, and hom/hom animals and wildtype (wt/wt) animals were used as control.
- For the triple transgenic E85-hQC model the E8 and E5 alleles were always double heterozygous (het/het) and wt, and hom of the hQC allele was used.
