Quantification of the identified nerves from Na
1.7 immunoreactivity and Sihler staining. A – Number of intrapapillary nerves per papillae showing NaV1.7 immunoreactivity. There were significant differences between the sites (1-way ANOVA, p < 0.01, F(3,170 = 5.174); the heel (post-hoc, p < 0.05) and arch (post-hoc, p < 0.01) had significantly lower nerve fiber densities than the dorsum. There were no statistically significant differences between the sites in the sole of the foot. B – No significant differences in the densities of intradermal nerve fibers were found between the sites stained with Sihler’s method (1-way ANOVA, p=0.994, F(2,8) = 0.006).