MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

BMC Neuroscience

Table 2 Receptor protein levels in human cerebral arteries

	Control	Organ.Culture	Organ Culture + treatment with U0126
ET_B (%) ± s.e.m	100 ± 6 ^a	128 ± 3 ^{a, b}	80 ± 4 ^b
ET_A (%) ± s.e.m	100 ± 4 ^a	137 ± 3 ^{a, b}	107 ± 4 ^b
TP (%) ± s.e.m	100 ± 3	119 ± 5	106 ± 3
AT₁ (%) ± s.e.m	100 ± 2 ^a	62 ± 4 ^a	82 ± 7
AT₂ (%) ± s.e.m	100 ± 2 ^a	120± 2 ^a	111 ± 1
5-HT_1B (%) ± s.e.m	100 ± 6 ^a	128 ± 3 ^{a, b}	84 ± 4 ^b
pERK1/2 (%) ± s.e.m	100 ± 2 ^a	128 ± 2 ^a,b	86 ± 2 ^b

Activation of the different protein levels measured with immunohistochemistry in human arteries. Values are expressed as percentage of control and given as mean ± s.e.m. ^a = significant difference between organ culture and control groups, ^b = significant difference between organ culture and organ culture treated with U0126.

ISSN: 1471-2202