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Table 1 Age by which a 50% decrease in the mean test performance of each group had occurred, or a 25% decrease in the case of the footprint test, within a confidence interval of one week, determined from the mathematical models established

From: Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

 

Amplitude of extension reflex score < 2.5

Rotarod time on rod < 90 s

Symmetry of extension reflex score < 1

Stride length < 5 cm

hA30Pα-syn+/+

18.1 ± 0.2 months

19.3 ± 0.2 months

20.0 ± 0.2 months

20.7 ± 0.2 months

parkin+/-; hA30Pα-syn+/+

18.4 ± 0.2 months

20.2 ± 0.2 months

22.3 ± 0.2 months

23.0 ± 0.2 months

parkin-/-; hA30Pα-syn+/+

21.0 ± 0.2 months

23.2 ± 0.2 months

23.4 ± 0.2 months

> 24 months