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Figure 6 | BMC Neuroscience

Figure 6

From: Parkinson’s disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein

Figure 6

Effect of increased α SYN flux in the dopaminergic nerve cell. The four diagrams show the flux changes while the αSYN input flux is increased from 0 to 100 μM·h−1. Sub-diagram A and B depict the results of the FBA with target function maxDeg. Sub-diagram C and D display the results of the FBA with target function minApo. Sub-diagram A and C summarize all fluxes that produce ROS and/or cause damage in the cell. In contrast, sub-diagram B and D contain all fluxes that are considered responses or consequences of fluxes shown in sub-diagram A to retain the normal cellular function.

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