Table 2 Regression formula for hypotheses 1A and 2A
From: Method parameters’ impact on mortality and variability in rat stroke experiments: a meta-analysis
Regression formula for the effect of Strain and Type of middle cerebral artery occlusion procedure on Infarct size coefficient of variation (hypotheses 1A and 2A) | |||||
|---|---|---|---|---|---|
Variable (reference category) | Variable categories | Regression coefficient | 0.95 confidence interval for regression coefficient | p-value | |
Constant | NA | 23.1 | 8.3 | 38.0 | 0.002 |
Strain (Sprague Dawley) | Wistar | −6.2 | −11.5 | −0.9 | 0.023 |
SHR | −1.7 | −11.0 | 7.5 | 0.710 | |
WKY | 19.0 | −0.8 | 38.8 | 0.059 | |
Other Strains | 20.7 | 10.7 | 30.8 | 0.000 | |
Type of middle cerebral artery occlusion procedure (Intraluminal filament) | Direct, mechanical | 4.2 | −3.4 | 11.8 | 0.274 |
Embolic | 14.7 | 3.4 | 26.0 | 0.011 | |
Photothrombotic | 10.1 | −5.2 | 25.5 | 0.196 | |
Endothelin injection | 23.1 | 9.3 | 36.9 | 0.001 | |
Sex (Male) | Female | −0.6 | −19.7 | 18.5 | 0.951 |
Ovx female | 2.3 | −16.7 | 21.4 | 0.810 | |
Mix or not specified | −11.5 | −21.5 | −1.5 | 0.024 | |
Elderly rats | [Yes] | −23.6 | −39.6 | −7.7 | 0.004 |
Weight | [Continuous; Grams] | 0.1 | 0.0 | 0.1 | 0.001 |
Type of anesthetic (Inhalation anesthetic) | Chloral Hydrate | −11.5 | −16.9 | −6.1 | 0.000 |
Ketamine | 2.9 | −4.4 | 10.2 | 0.430 | |
Barbiturates and bensodiazepines | −8.4 | −17.6 | 0.9 | 0.076 | |
Other anesthetic | −13.6 | −22.6 | −4.6 | 0.003 | |
Awakening of rats during occlusion (No) | [Yes] | 8.8 | 0.9 | 16.7 | 0.028 |
Temperature feedback system (No) | [Yes] | −6.9 | −12.4 | −1.5 | 0.013 |
Blood hemoglobin concentration analyzed (No) | [Yes] | 10.9 | 3.0 | 18.8 | 0.007 |
Occlusion duration (Short transient) | Long transient | 1.9 | −3.9 | 7.8 | 0.519 |
Permanent | −16.6 | −24.1 | −9.1 | 0.000 | |
Time after focal ischemia for evaluation of damage | [Continuous; Hours] | 0.0051 | 0.0005 | 0.0096 | 0.030 |
Criteria for excluding rats (None) | Observed absence of cerebral blood flow reduction | −7.7 | −12.4 | −2.9 | 0.002 |
Lack of functional deficit | −2.9 | −8.6 | 2.7 | 0.310 | |
Too small infarct | 0.1 | −9.6 | 9.9 | 0.981 | |
Other pathology in animal | 18.6 | 12.7 | 24.6 | 0.000 | |