Table 4 Regression formula for hypothesis 3A
From: Method parameters’ impact on mortality and variability in rat stroke experiments: a meta-analysis
Regression formula for the effect of Occluding filament type on Infarct size coefficient of variation (hypothesis 3A) | |||||
|---|---|---|---|---|---|
Variable (reference category) | Variable categories | Regression coefficient | 0.95 confidence interval for regression coefficient | p-value | |
Constant | NA | 49.1 | 38.7 | 59.4 | 0.000 |
Occluding filament type (Uncoated) | Silicon coated | −12.7 | −18.3 | −7.0 | 0.000 |
Poly-L-Lysine coated | 3.1 | −4.8 | 11.0 | 0.444 | |
Other coatings | 3.1 | −5.0 | 11.3 | 0.451 | |
Strain (Sprague Dawley) | Wistar | −2.1 | −8.3 | 4.1 | 0.507 |
SHR | −3.0 | −17.2 | 11.2 | 0.679 | |
WKY | 16.1 | −5.6 | 37.8 | 0.146 | |
Other Strains | 25.9 | 11.0 | 40.7 | 0.001 | |
Sex (Male) | Female | 3.3 | −17.0 | 23.7 | 0.747 |
Ovx female | 12.1 | −8.5 | 32.6 | 0.248 | |
Mix or not specified | −5.0 | −15.1 | 5.2 | 0.335 | |
Elderly rats | [Yes] | −17.8 | −38.4 | 2.9 | 0.091 |
Type of anesthetic (inhalation anesthetic) | Chloral Hydrate | −12.0 | −18.7 | −5.4 | 0.000 |
Ketamine | 4.5 | −4.3 | 13.2 | 0.315 | |
Barbiturates and bensodiazepines | −12.4 | −24.8 | 0.00 | 0.050 | |
Other anesthetic | −14.2 | −24.1 | −4.4 | 0.005 | |
Awakening of rats during occlusion (No) | [Yes] | 10.4 | 2.1 | 18.6 | 0.014 |
Temperature feedback system (No) | [Yes] | −7.6 | −14.1 | −1.2 | 0.021 |
Blood pressure monitored (No) | [Yes] | −12.0 | −21.4 | −2.6 | 0.013 |
Heart rate monitored (No) | [Yes] | 14.9 | 5.4 | 24.4 | 0.002 |
Blood gases/O 2 saturation analyzed (No) | [Yes] | 11.5 | 1.8 | 21.1 | 0.021 |
Blood hemoglobin concentration analyzed (No) | [Yes] | 10.7 | 1.5 | 19.9 | 0.023 |
Occlusion duration (Short transient) | Long transient | −3.3 | −9.3 | 2.8 | 0.288 |
Permanent | −21.4 | −30.1 | −12.8 | 0.000 | |
Time after focal ischemia for evaluation of damage | [Continuous; Hours] | 0.000036 | −0.000013 | 0.000087 | 0.157 |
Blinding of infarct size determination procedure (No) | [Yes] | −3.8 | −9.9 | 2.2 | 0.211 |
Criteria for excluding rats (None) | Observed absence of cerebral blood flow reduction | −7.4 | −13.1 | −1.7 | 0.011 |
Lack of functional deficit | −5.6 | −12.0 | 0.7 | 0.083 | |
Too small infarct | 7.6 | −4.5 | 19.6 | 0.219 | |
Other pathology in animal | 16.2 | 8.7 | 23.6 | 0.000 | |