Task/marker | DAPT | CHF5074 |
---|---|---|
Novel object recognition test (recognition index) | unchanged | restored at wild-type level at 375ppm |
amyloid plaque burden | unchanged | reduced |
oligomers | Â | Â |
plasma Aβ42 | increased | increased at 375ppm |
intraneuronal Aβ | reduced | reduced |
microglia activation (Iba1-IR) | unchanged | reduced |
Dendritic spine density (CA1/2 pyramidal neurons) | restored at wild-type level | increased at 375ppm, compared to Tg2576 vehicle |
Aberrant cell cycle events (cyclinA-IR neurons) | lightly reduced (−28%) | strongly reduced (−63%) |