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Table 2 Experimentally determined hydrodynamic radii and observed permeability coefficients across RBEC monolayers for Lucifer yellow and FITC-dextrans

From: Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitromodels of the rat blood-brain barrier and blood-spinal cord barrier

   Molecule

Molecular weight (kDa)

Hydrodynamic radius (nm)

Mean paracellular transport (× 10-6 cm/sec)

SEM (× 10-6 cm/sec)

Lucifer Yellow

0.5

0.49

2.22

0.137

4 kDa FITC-Dextran

4

1.40

1.00

0.201

10 kDa FITC-Dextran

10

2.30

0.46

0.117

20 kDa FITC-Dextran

20

3.30

0.38

0.142

40 kDa FITC-Dextran

40

4.50

0.16

0.038

70 kDa FITC-Dextran

70

6.00

0.14

0.049

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BMC Neuroscience

ISSN: 1471-2202

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