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Figure 6 | BMC Neuroscience

Figure 6

From: Contribution of different classes of glutamate receptors in the corticostriatal polysynaptic responses from striatal direct and indirect projection neurons

Figure 6

More polysynaptic GABAergic inputs are evoked after cortical stimulation. A: A dSPN corticostriatal response before (red trace) and after the GABAA-receptors antagonist, 10 μM bicuculline (black trace), were added to the bath saline. B: Similar experiment in the same dSPN but using intrastriatal stimulation. Bicuculline reduced both responses. C, D: subtraction of responses in A and B: bicuculline reduced the responses in both cases. Both responses exhibit hyperpolarizing and depolarizing phases (with respect to firing threshold). E: A iSPN corticostriatal response before (green trace) and after 10 μM bicuculline (black trace). F: Similar experiment in the same iSPN but using intrastriatal stimulation. Bicuculline enhanced both responses. G, H: subtraction of responses in E and F: both responses exhibit hyperpolarizing actions (with respect to firing threshold).

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BMC Neuroscience

ISSN: 1471-2202

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