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Figure 5 | BMC Neuroscience

Figure 5

From: Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2−/− as well as Slit1−/−Slit2−/−embryos

Figure 5

Axonal defects in Slit2−/−and Slit1−/−Slit2−/−embryos occur where Slit2 is normally expressed. (A) The area of axonal analysis is superimposed on an in situ hybridization for Slit2. Scale bar = 200 μm. (B-D) Mean vector orientation (red/magenta), direction and magnitude of curvature (green) and magnitude and direction of Slit2 gradient (yellow) are shown for each grid square for each genotype shown. Wild-type, n = 9; Slit2−/−, n = 5; Slit1−/−Slit2−/−, n = 4. Data are superimposed on an image showing the average intensities within each grid square of Slit2 expression in wild-types (n = 3 in situ hybridizations).

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