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Inhibitory STDP improves temporal processing in disynaptic circuits
© Kleberg et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Synaptic Plasticity
- Spike Train
- Synaptic Weight
- Detailed Balance
- Inhibitory Neuron
Spike trains with temporal correlations have been related to cognitive and sensory processing , and extraction of correlation information may therefore be of great importance to neuronal computations. Synaptic plasticity rules such as Spike-Timing Dependent Plasticity (STDP) allow selective increases of synaptic weights that receive correlated spike input, allowing the neuron to detect correlation in its input [2, 3]. Though this has been shown in excitatory synapses, only few studies have addressed the functional properties of STDP in inhibitory synapses [4, 5].
It is known that excitatory and inhibitory activities are typically balanced , and maintenance of a 'detailed balance' within signaling pathways has been shown to achieve useful gating properties . Therefore, combining plasticity mechanisms in excitatory and inhibitory weights in the same model could provide insight in how such a balance can arise, and what possible functions inhibitory synaptic plasticity can fulfill in the presence of input spike trains with varying statistics.
Our findings provide insight in the role of inhibitory STDP, in maintaining detailed balance and enhancing transmission efficacy in disynaptic neural circuits.
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