Inhibitory STDP improves temporal processing in disynaptic circuits
© Kleberg et al; licensee BioMed Central Ltd. 2013
Published: 8 July 2013
Spike trains with temporal correlations have been related to cognitive and sensory processing , and extraction of correlation information may therefore be of great importance to neuronal computations. Synaptic plasticity rules such as Spike-Timing Dependent Plasticity (STDP) allow selective increases of synaptic weights that receive correlated spike input, allowing the neuron to detect correlation in its input [2, 3]. Though this has been shown in excitatory synapses, only few studies have addressed the functional properties of STDP in inhibitory synapses [4, 5].
It is known that excitatory and inhibitory activities are typically balanced , and maintenance of a 'detailed balance' within signaling pathways has been shown to achieve useful gating properties . Therefore, combining plasticity mechanisms in excitatory and inhibitory weights in the same model could provide insight in how such a balance can arise, and what possible functions inhibitory synaptic plasticity can fulfill in the presence of input spike trains with varying statistics.
Our findings provide insight in the role of inhibitory STDP, in maintaining detailed balance and enhancing transmission efficacy in disynaptic neural circuits.
- Riehle A, Gruen S, Diesmann M, Aertsen A: Spike Synchronization and rate modulation differentially involved in motor cortical function. Science. 1997, 278: 1950-1953. 10.1126/science.278.5345.1950.View ArticlePubMedGoogle Scholar
- Song S, Abbott LF: Cortical development and remapping through spike-timing dependent plasticity. Neuron. 2001, 32: 339-350. 10.1016/S0896-6273(01)00451-2.View ArticlePubMedGoogle Scholar
- Gilson M, Fukai T: Stability versus neuronal specialization for STDP: Long-tail weight distributions solve the dilemma. Plos One. 2011, 6 (10): e25339-10.1371/journal.pone.0025339.PubMed CentralView ArticlePubMedGoogle Scholar
- Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W: Inhibitory Plasticity balances excitation and inhibition in sensory pathways and memory networks. Science. 2011, 334: 1569-1573. 10.1126/science.1211095.View ArticlePubMedGoogle Scholar
- Luz Y, Shamir M: Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity. Plos Comp Biol. 2012, 8: e1002334-10.1371/journal.pcbi.1002334.View ArticleGoogle Scholar
- Shu Y, Hasenstaub A, McCormick DA: Turning on and off recurrent balanced cortical activity. Nature. 2003, 423: 288-293. 10.1038/nature01616.View ArticlePubMedGoogle Scholar
- Vogels TP, Abbott LF: Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. Nat Neurosci. 2009, 12: 483-491. 10.1038/nn.2276.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.