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Table 1 Predicted Effectiveness of AED Target

From: Designing anti-epileptic drugs using neuronal dynamics

Parameter (Current) PRC SSE Parameter (Current) PRC SSE Parameter (Current) PRC SSE Parameter (Current) PRC SSE
theta nt (KDR) 10.8 sigma a (KA) 39.2 theta m (Na) 86.9 sigma n (KDR) 106.5
theta b (KA) 21.4 sigma nt (KDR) 41.2 sigma ht (Na) 90.2 theta p (NaP)1 108.4
theta a (KA) 22.4 sigma h (Na) 51.3 gL (Leak) 94.7 theta h (Na)1,3-7 115.9
gKA (KA) 26.1 theta ht (Na) 54.4 sigma p (NaP) 100.0 theta z (Kslow) 134.4
sigma b (KA) 28.4 gKSlow (Kslow) 74.8 sigma m (Na) 101.7 sigma z (Kslow) 138.9
gKDR (KDR) 38.1 gNa (Na) 82.0 gNaP (NaP) 102.7 theta n (KDR)2 156.3
  1. Each parameter studied was ranked according the sum squared error of its measured PRC compared to the measured control PRC. Known convulsant drug, 4-aminopyridine (2), ranks last with the greatest error of the PRC, while known AED phenytoin (1) ranks higher. The top ranking currents are all associated with K+ currents that currently have no associated AEDs, but in recent years K+ channels have been seen as potential targets after the success of the drug retigabine. In this model, the K+ M-current is part of the conglomerate Kslow current making commentary difficult. Other AEDs not examined in this study: valproate (3), topiramate (4), carbamazepine (5), oxcarbazepine (6), lamotrigine (7) also stabilize Na+ inactivation.