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Table 1 Nerve regeneration after nerve injury and repair in healthy and diabetic rats

From: Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

 

Healthy male

Healthy female

Diabetes male

Diabetes female

p-values (KWa)

Fisher’s methodb

(n = 10)

(n = 10)

(n = 10)

(n = 10)

 

Male/female

Healthy/Diabetes

Axonal outgrowth (neurofilaments, mm)

7.0 (6.8-7.3)

6.3 (6.1-6.4)

6.9 (6.7-7.1)

5.8 (5.1-6.2)

0.0001

<0.0001

0.02

ATF-3 (% of total) SNL

17.8 (17.6-18.4)

17.6 (16.7-18.0)

19.8 (19.1-21.1)

16.4 (15.7-17.3)

0.0001

0.0001

0.001

ATF-3 (% of total) SND

19.2 (17.7-19.6)

19.5 (18.9-20.1)

18.7 (16.9-20.1)

15.2 (14.4-15.7)

0.0001

0.0003

0.001

Cleaved caspase-3 (% of total) SNL

5.2 (2.6-7.8)

3.1 (2.9-3.4)

9.6 (8.7-11.6)

7.0 (6.4-10.1)

0.0001

0.31

<0.0001

Cleaved caspase-3 (% of total) SND

2.7 (2.2-4.0)

2.5 (2.4-2.7)

6.4 (4.5-7.1)

5.8 (4.3-6.1)

0.0001

0.39

<0.0001

Total cell number (mm 2 ) SNL

1137 (1127-1142)

1050 (1027-1066)

1073 (1046-1103)

1089 (1059-1098)

0.0001

0.0007

0.0001

Total cell number (mm 2 ) SND

1137 (1122-1152)

1112 (1068-1147)

1053 (1019-1091)

1093 (1045-1102)

0.0001

0.07

<0.0001

Preoperative B-glucose (mmol/l)

4.6 (4.3-4.9)

3.90 (3.8-4.3)

15.0 (13.3-17.2)

10.3 (9.7-11.7)

0.0001

<0.0001

<0.0001

Weight increase (%)

2.2 (0.7-2.7)

2.4 (1.3-4.8)

2.0 (1.2-2.6)

2.6 (2.0-3.2)

0.34

-

-

  1. Values are median 25th (Q1) -75th (Q3) percentiles. aKW = Kruskal-Wallis. bFisher’s method for independent samples based on the chi square distribution. SNL = Lesion site. SND = Distal nerve segment. Total cell = DAPI stained cells. P-values in bold is significantly different at least at the 0.05 level.