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Figure 7 | BMC Neuroscience

Figure 7

From: Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function

Figure 7

Synergistic effect of MS-MPs and thrombin on endothelial barrier function. Top graph. Representative experiment in which HUVECs were incubated with MPs at concentrations between 250 and 1000 MP/μl for 22 h. Then, 1 U/ml of thrombin was added to those monolayers showing no alteration of TEER in response to MPs. After thrombin-induced acute contraction and subsequent barrier recovery, HUVECs preincubated with RRMS MPs (RR3) undergo long-term decrease in TEER. Bottom table. Percentage of Control (3 samples), CIS (2 samples), and RR-MPs (3 samples) in which 500 MP/μl had no apparent effect on barrier function, but induced long-term TEER decrease after thrombin stimulation.

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