Figure 3

Dynamics of the neuronal avalanche in enhanced network activity. A, Typical traces of seizure-like activity with the application of low (5 μM) and high (50 μM) Bic concentrations. B-C, Comparison of amplitude, duration, average discharge, and inter-seizure interval (ISI) in a bar chart. D, Color map of isopotential, 2D-CSD, and correlation coefficient. E-G, 2D-CSD in the ictal/tonic and clonic phases of seizure activity. H-I, Power spectrum of FFT and statistical bar chart. J, Coherence of each frequency band in the vertical and horizontal directions. K-M, Avalanche size and lifetime distribution on a log-log scale. The shuffled groups showed a Poisson distribution (dash line). The statistical bar chart indicates that the avalanche size increased significantly after the application of the high concentration of Bic. *p < 0.01.