Figure 3

Effect of aripiprazole on ERK phosphorylation in C57Bl/6 mouse prefrontal cortex in the absence or presence of AG1478 (EGF receptor inhibitor). Representative blots (A) indicate immunoreactive bands of phosphorylated ERK1 and phosphorylated ERK2 (upper panel) and total ERK1 and total ERK2 (lower panel) levels following aripiprazole (1 mg/kg) ± AG1478 treatment and correspond with the bar graphs below. (B) Effect of AG1478 on aripiprazole induced ERK1 phosphorylation at 60 min. (C) Effect of AG1478 on aripiprazole induced ERK2 phosphorylation at 60 min. Data are expressed relative to vehicle control standardized to 100 percent and represent the mean ± SEM of at least four mice per experimental group. **p < 0.01, statistical differences between tissue in the absence (V) and presence of aripiprazole are indicated. V = Vehicle, Ari = Aripiprazole.