Figure 6

Effect of quetiapine on p90RSK phosphorylation in C57Bl/6 mouse prefrontal cortex and striatum. Representative blots (A) prefrontal cortex and (C) striatum indicate immunoreactive bands of phospho-p90RSK (upper panel) and RSK1/RSK2/RSK3 (lower panel) following quetiapine (5 mg/kg) treatment and correspond with the bar graph below. (B) Quetiapine treatment over a 24 hr period - prefrontal cortex. (D) Quetiapine treatment over a 24 hr period - striatum. At each time point treated samples were expressed relative to vehicle control standardized to 100 percent. Data represent the mean ± SEM of at least four mice per experimental group. *p < 0.05; **p < 0.01, statistical differences between tissue in the absence (vehicle) and presence of quetiapine are indicated.