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Table 2 Summary of the variations from NAc metabolites in mice

From: 1H-Nuclear magnetic resonance-based metabolomic analysis of brain in mice with nicotine treatment

Metabolites

Chemical shift

Control-nicotine

 

(ppm)

VIPa

Loadingb

Glutamate

2.08

5.02

+0.369

Isoleucine

1.28

4.46

+0.331

1 -Methyihistamine

3.68

2.99

+0.223

Cystine

3.36

2.96

+0.068

2-Ketobutyric acid

2.76

2.24

+0.162

Lactate

1.32

2.11

+0.148

Tryptamine

7.32

2.09

+0.155

Glycerol

3.64

2.04

+0.153

Glucose

3.40

1.92

+0.066

3 -Hydroxybutyric acid

1.20

1.90

+0.142

  1. aVariable importance in the projection (VIP ≥ 1) was obtained from OSC-PLS.
  2. bLoading: the positive (+) value represents an increase of the metabolite in the second group of the subtitle (e.g.: Control → Nicotine).