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Figure 5 | BMC Neuroscience

Figure 5

From: Chronic alcohol consumption from adolescence-to-adulthood in mice - hypothalamic gene expression changes in the dilated cardiomyopathy signaling pathway

Figure 5

Hypothesis of adolescent chronic alcohol consumption effect on SPIF gene down regulation in the dilated cardiomyopathy signaling pathway. Diagram was adapted from KEGG pathway (http://www.genome.jp/kegg/) [92] for dilated cardiomyopathy (DCM), showing the β1AR-DHPR-Ca2+ branch of the DCM pathway. Adolescent chronic alcohol consumption is hypothesized to result in the down regulation of SPIF genes (marked with grey color and solid down arrows), including β1-adrenergic receptor (Adrb1), Gs protein (Gnas), adenylyl cyclase 1 (Adcy1), and dihydropyridine receptor/L-type calcium channel (Cacna1d). The coordinated down regulation of these SPIF genes leads to impaired intracellular Ca2+ homeostasis at the cellular level.

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BMC Neuroscience

ISSN: 1471-2202

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