Figure 3

Temporal change in anxiety-like behavior in the EPM following acute CORT treatment. The increased anxiety level 12 days after acute CORT treatment was evident by a decrease in open arm duration (A) and a decrease in total number of open arm entry (B). *, P < 0.05 (post hoc Bonferroni test). No difference in total moving distance between vehicle- and CORT-treated groups indicates that the higher anxiety-level was not accompanied by difference in locomotion activity (C).