Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia

BMC Neuroscience

Table 2 Gene Set Enrichment Analysis (GSEA) results

Time of sacrifice	Gene set name	Description	NES	FDR q-value	Direction	Experimental group
6 h	KEGG:04141	Protein processing in endoplasmatic reticulum	2.54	<0.001	↑	PA and FAPA
	PF01352	KRABbox	2.42	<0.001	↑	FAPA
	PF00956	Nucleosome assembly protein	2.14	<0.01	↑
	KEGG:00970	Aminoacyl-tRNA biosynthesis	2.47	<0.001	↑
	KEGG:00510	N-glycan biosynthesis	2.04	<0.01	↑
	KEGG:00100	Steroid biosynthesis	-2.58	<0.001	↓
96 h	GO:0005746	Mitochondrial respiratory chain	-2.20	<0.01	↓	PA and FAPA
	KEGG:00190	Oxidative phosphorylation	-2.34	<0.001	↓
	GO:0001505	Regulation of neurotransmitter levels	-2.22	<0.01	↓	PA
	GO:0007268	Synaptic transmission	-2.11	<0.01	↓
	GO:0007269	Neurotransmitter secretion	-2.23	<0.01	↓
	KEGG:04020	Calcium signaling pathway	-1.97	<0.01	↓
	KEGG:04970	Salivary secretion	-2.16	<0.01	↓
	KEGG:04971	Purine metabolism	-2.04	<0.01	↓
	PF00089	Trypsin	2.23	<0.01	↑	FAPA
	GO:0019208	Phosphatase regulator activity	-2.09	<0.01	↓
	KEGG:03010	Ribosome	-2.237	<0.001	↓
	BIOCARTA_PGC1APATHWAY		-2.09	<0.01	↓

Significantly enriched gene sets found with GSEA using the FDR q-value <0.01 as cut-off for significance. NES = Normalized Enrichment Score. FDR q-value = False Discovery Rate method of correction for multiple testing. (PA: experimental group only subjected to perinatal asphyxia. FAPA: experimental group subjected to both fetal preconditioning and perinatal asphyxia).

ISSN: 1471-2202