Figure 1

Effects of mirtazapine on MPTP-induced motor dysfunctions in mice using beam-walking test and rota-rod test. (A) Beam-walking test: Vertical axis shows the periods required to traverse 50 cm of the beam. (B) Rota-rod test: Vertical axis shows the latency to fall from the rotating rod after the mice were placed on it. Values are expressed as means ± SEM, n = 9–10 mice/group. Mirt.(4), mirtazapine 4 mg/kg; Mirt.(16), mirtazapine 16 mg/kg. Statistical significance was evaluated by one-way ANOVA followed by Scheffe test (F_{(A) 4,44} = 9.803, F_{(B) 4,44} = 7.341, *P < 0.05, **P < 0.01 compared with MPTP-treated group).