Dopamine | DOPAC | HVA | Turnover rate | |
---|---|---|---|---|
Vehicle | 19.49 ± 0.75** | 1.62 ± 0.12** | 1.03 ± 0.04** | 0.14 ± 0.01 |
WAY100635 (0.05 mg/kg) | 18.22 ± 1.21** | 1.73 ± 0.09** | 0.91 ± 0.04** | 0.15 ± 0.01 |
prazosin (0.03 mg/kg) | 20.27 ± 2.33** | 1.51 ± 0.14** | 0.79 ± 0.09** | 0.12 ± 0.01# |
clonidine (0.15 mg/kg) | 22.76 ± 1.88** | 1.47 ± 0.07** | 0.84 ± 0.05** | 0.10 ± 0.01## |
MPTP | 3.38 ± 0.35 | 0.51 ± 0.05 | 0.44 ± 0.04 | 0.28 ± 0.01## |
MPTP + mirtazapine (16 mg/kg) | 1.90 ± 1.21 | 0.38 ± 0.08 | 0.29 ± 0.06 | 0.78 ± 0.25* |
MPTP + mirtazapine (16 mg/kg) + WAY100635 (0.05 mg/kg) | 2.25 ± 0.47 | 0.40 ± 0.10 | 0.32 ± 0.08 | 0.33 ± 0.05† |
MPTP + mirtazapine (16 mg/kg) + prazosin (0.03 mg/kg) | 3.49 ± 0.48 | 0.56 ± 0.04 | 0.37 ± 0.01 | 0.28 ± 0.03† |
MPTP + mirtazapine (16 mg/kg) + clonidine (0.15 mg/kg) | 2.90 ± 0.68 | 0.58 ± 0.68 | 0.45 ± 0.07 | 0.31 ± 0.04† |