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Table 1 Changes in α4YFP* nAChR expression with chronic nicotine exposure in α4YFP knock-in mice in this study as compared to Nashmi et al. [7]

From: Chronic nicotine pretreatment is sufficient to upregulate α4* nicotinic receptors and increase oral nicotine self-administration in mice

   α4YFP* nAChR Upregulation (% of saline)
Brain Region Cell Type This study Nashmi et al. [7]
Perforant Path Glutamatergic 189 ± 16 (p = 0.001) 194 ± 2 (p < 0.001)
Medial Habenula Cholinergic 114 ± 17 (ns) 112 ± 4 (ns)
VTA GABAergic 157 ± 10 (p = 0.005) 136 ± 7 (p = 0.002)
  Dopaminergic 92 ± 8 (ns) 109 ± 3 (ns)
  1. ns = not significantly different from saline treated animals.