- Oral presentation
- Open Access
Determinants of gain modulation enabled by short-term depression at an inhibitory cerebellar synapse
BMC Neuroscience volume 15, Article number: O11 (2014)
Neurons adapt rapidly the slope, also known as gain, of their input-output function to time-varying conditions. Gain modulation is a prominent mechanism in many brain processes, such as auditory processing and attention scaling of orientation tuning curves. It is known to amplify neuronal signals, prevent firing saturation, and play a key role in coordinate transformation .
Synaptic short-term depression (STD) at the excitatory synapse from mossy fibres (MFs) to granule cells in the cerebellum has previously been found to introduce a gain change, and enhance inhibition-mediated gain modulation . Similar results were discovered for STD at the inhibitory synapse from Purkinje cells (PCs) to cerebellar nucleus (CN) neurons, where STD modulates gain and enhances excitation-mediated gain modulation . In both cases – whether STD is applied at the excitatory or inhibitory synapse, respectively – the non-linearity introduced by STD in the relationship between input firing rate and average conductance, was found to underlie the effects of STD.
We use a multi-compartmental model of a cerebellar nucleus neuron  to understand how STD at an inhibitory synapse can add a multiplicative component in the transformation performed by excitatory input. To do so, we use input from PCs, applied at an inhibitory synapse with STD, and excitatory input from MFs, while changing the level of STD by manipulating the presynaptic release probability (R) . We find that gain modulation resulting from the introduction of STD increases with the extent of depression. To further our understanding, we investigate the effects of STD using synchronous input, regular input, and their combination. We find that the multiplicative component introduced by STD remains, but varies in value for different input conditions. Moreover, we present a detailed analysis of how a non-linear mapping between input spike rate and synaptic conductance can result in multiplicative operations.
Silver RA: Neuronal arithmetic. Nature Reviews Neuroscience. 2010, 11: 474-489. 10.1038/nrn2864.
Rothman JS, Cathala L, Steuber V, Silver RA: Synaptic depression enables neuronal gain control. Nature. 2009, 457: 1015-1018. 10.1038/nature07604.
Bampasakis D, Maex R, Davey N, Steuber V: Short-term depression of inhibitory Purkinje cell synapses enhances gain modulation in the cerebellar nuclei. BMC Neuroscience. 2013, 14: 374-10.1186/1471-2202-14-S1-P374.
Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D: Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of Computational Neuroscience. 2011, 3 (3): 633-58. 10.1007/s10827-010-0282-z.
Shin SL, Hoebeek F, Schonewille M, De Zeeuw CI, Aertsen A, De Schutter E: Regular patterns in cerebellar Purkinje cell simple spike trains. PloS One. 2007, 2 (5): e485-10.1371/journal.pone.0000485.
About this article
Cite this article
Bampasakis, D., Maex, R., Davey, N. et al. Determinants of gain modulation enabled by short-term depression at an inhibitory cerebellar synapse. BMC Neurosci 15, O11 (2014). https://0-doi-org.brum.beds.ac.uk/10.1186/1471-2202-15-S1-O11
- Cerebellar Nucleus
- Excitatory Input
- Inhibitory Synapse
- Gain Modulation
- Synaptic Conductance