Modeling mGluR1 mediated synaptic depression in cerebellar Purkinje cells
© Su and Lu; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
The synaptic depression mediated by TRPC channel current is successfully simulated in the local model. Synchronized train stimulation to the spines in the full model of Purkinje cell were able to cause the cell to fire then followed by a gap in spiking caused by the reduction in the gmax of AMPA channels. Once the TRPC current passed the rising phase, the firing resumed. This model will be used to guide the in vitro experiments to study the interaction of TRPC current mediated depression with simple spike activities. Once the second messenger(s) and the delay time of the plastic effects are know, this model can be further used to study the function of cerebellar LTD.
We thank the support of CSO fund from PCOM to provide computers for simulation. We also thank Drs. Cornelis and Beeman for their help through firstname.lastname@example.org.
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