- Poster presentation
- Open Access
Partial correlation analysis for functional connectivity studies in cortical networks
© Poli et al; licensee BioMed Central Ltd. 2014
- Published: 21 July 2014
- Receiver Operating Characteristic
- Functional Connectivity
- Partial Correlation
- Neural Network Model
- Neuronal Network
The use of in vitro neuronal systems and computational models has strongly contributed to the better understanding of relevant neurophysiological principles. Taking advantages form these approaches, here we propose a revised method of partial correlation analysis to investigate functional connectivity in neuronal networks.
The main goal of this work is to estimate the functional connectivity, by means of correlation and information theory-based methods, from the spontaneous activity of dissociated cortical neurons developing in vitro and coupled to micro-electrode arrays (MEAs). In particular we focused here on the Partial Correlation (PC) method  compared to Transfer Entropy  and Cross Correlation (CC)  algorithms.
Second we assessed the statistical significance of connections extracted through the aforementioned algorithms from electrophysiological data. Using “shuffling” techniques devised in , we implemented a reliable threshold-independent test, model free and not linked to any particular initial assumptions (i.e., choice of data distribution).
Finally, applying the validated methods, we obtained functional mapping of biological in vitro models of cortical networks and we extracted relevant topological features.
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