# Table 1 Summary of statistical analyses for 4 dependent measures. Each dependent variable was analyzed in a Cage Familiarity (CAGE) by Time of Cage Introduction (INTRO) by Hour of Testing (HOUR) by Drug Treatment (DRUG) ANOVA with repeated measures on the first 3 factors.

Visits to Home Base from
Distance Traveled Duration of Staying in Cage Exits from Cage Phase 1
Source df Mean Square F Sig. Mean Square F Sig. Mean Square F Sig. Mean Square F Sig.
Within-Subjects Contrasts
INTRO 1 2224908867 22.9 0.000 16232863 79.8 0.000 3317 8.9 0.007 19320 24.6 0.000
INTRO * DRUG 1 1839965205 19.0 0.000 588913 2.9 0.103 3468 9.3 0.006 16725 21.3 0.000
Error(INTRO) 22 97033892    203487    373    784
CAGE 1 17701171788 375.4 0.000 169590106 419.9 0.000 4720 8.1 0.009 141484 33.0 0.000
CAGE * DRUG 1 17751213019 376.4 0.000 6113519 15.1 0.001 2228 3.8 0.063 137281 32.0 0.000
Error(CAGE) 22 47154899    403928    581    4289
HOUR 1 237500968 2.7 0.115 23543456 100.6 0.000 5355 12.4 0.002 1151 2.2 0.153
HOUR * DRUG 1 21492295 0.2 0.627 531418 2.3 0.146 7203 16.7 0.000 7 0.0 0.911
Error(HOUR) 22 88224156    234028    431    526
INTRO * CAGE 1 931631085 15.2 0.001 13760369 64.5 0.000 893 4.0 0.059 7033 5.4 0.029
INTRO * CAGE * DRUG 1 735495405 12.0 0.002 306872 1.4 0.243 721 3.2 0.087 7057 5.5 0.029
Error(INTRO*CAGE) 22 61156552    213365    225    1293
INTRO * HOUR 1 2609009790 29.3 0.000 21625057 225.4 0.000 30 0.3 0.610 29800 31.4 0.000
INTRO * HOUR * DRUG 1 4087487232 45.9 0.000 1798563 18.7 0.000 609 5.4 0.029 31468 33.1 0.000
Error(INTRO*HOUR) 22 89134994    95927    112    950
CAGE * HOUR 1 3303732675 57.1 0.000 23390748 104.8 0.000 2961 12.4 0.002 33867 25.1 0.000
CAGE * HOUR * DRUG 1 3331266987 57.6 0.000 327649 1.5 0.238 2523 10.5 0.004 33602 24.9 0.000
Error(CAGE*HOUR) 22 57815111    223114    240    1348
INTRO * CAGE * HOUR 1 4645326525 153.7 0.000 19868514 195.9 0.000 363 3.0 0.099 17710 40.9 0.000
INTRO * CAGE * HOUR *
DRUG 1 4897187026 162.1 0.000 1727200 17.0 0.000 1764 14.4 0.001 17749 41.0 0.000
Error(INTRO*CAGE*HOUR) 22 30215914    101397    123    433
Between-Subjects Effects
DRUG 1 73038969284 146.9 0.000 7882396 20.3 0.000 13635 17.2 0.000 509438 61.9 0.000
Error 22 497327329    387476    791    8236