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Figure 6 | BMC Neuroscience

Figure 6

From: ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

Figure 6

Peroxisomes participate in mitochondrial vacuolation. Spinal cord sections from SOD1G93A mice were stained with anti-SOD1 (red) and anti-catalase (green) antibodies (A-H), or anti-SOD1 (red) and anti-PMP70 (green) antibodies (I-L), and shown as 3-D reconstructed confocal images. C, G and K are superimpositions of the red and green signals. D and H are the same as C and G, respectively, but rotated to the right for 30°. L is the same as K but rotated for 90°. Arrows in B-D and F-H point to small, catalase-positive granules that line against the inner wall of vacuoles. Arrows in J-L point to small, PMP70-positive granules that line against the inner wall of vacuoles. Notice one PMP-70 granule in J and K represents two granules when viewed at the 90° in L. Unfilled arrows point to granules that lie against the outer wall of the vacuoles.

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BMC Neuroscience

ISSN: 1471-2202

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