From: A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS
Animal | Sex | Survival | Age at death | SIVE | Reason for euthanasia | CNS histopathology | Non-CNS pathology |
---|---|---|---|---|---|---|---|
530–98 | M | 523 dpi | 1119 days est | Y | Weight loss; mild diarrhea | Moderate SIVE; meningo-encephalomyelitis due to CMV | Orchitis due to CMV; enterotyphlocolitis |
456–98 | F | 176 dpi | 948 days | Y | Weight loss; severe diarrhea | Mild SIVE | SIV giant cell pneumonia and PCP; mild enteritis |
526–98 | M | 153 dpi | 756 days est | N | Weight loss; diarrhea; anorexia | Mild perivascular accumulations of macrophages | Mild PCP and CMV in lung; glomerulonephritis |
520–98 | M | 293 dpi | 1254 days est | N | Severe oral disease | Mild perivascular edema | Ulcerative gingivitis and osteomyelitis; myocarditis |
202–98 | M | 742 dpi | 1648 days | N | Epistaxis; respiratory disease | No significant CNS pathology | Severe PCP |
513–98 | F | 726 dpi | 1694 days est | N | Termination of study | No significant CNS pathology | Vegetative endocarditis; fibrinous pleuritis |
104–98 | F | 735 dpi | 1646 days | N | Termination of study | No significant CNS pathology | Mild enteritis |
170–98 | F | 735 dpi | 1612 days | N | Termination of study | No significant CNS pathology | Vegetative endocarditis; severe protozoal gastritis |