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Figure 1 | BMC Neuroscience

Figure 1

From: The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

Figure 1

(A) Flow cytometric analyses of independent samples GD15 cortex show more cells expressing Fas immuno-fluorescence in samples #1–#4, compared to pre-immune serum control. Gate 'M' was set to exclude background fluorescence, or 98% of neuroblasts in the control sample (B & C) immunohistochemical analysis of cultured embryonic cortical neurons indicates Fas-immunoreactivity is localized to the soma and proximal processes (arrow). Immunohistochemical controls (arrow, C) show lack of staining in neurons. (D) Graph (Mean ± SEM) of the percentage of Fas-expressing precursors that also co-localize the pro-apoptotic DISC adapter protein FADD, or the anti-apoptotic inhibitor FLIP.

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BMC Neuroscience

ISSN: 1471-2202

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