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Figure 7 | BMC Neuroscience

Figure 7

From: The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

Figure 7

Estrogen suppresses Fas expression in adherent primary cortical precursors: (A) Sample flow cytometric scatter plots from two control and two E2 treated cultures, showing Fas intensity (y-axis) plotted against cell-cycle stage (PI intensity, x-axis). Scatter plots depict a general suppression in cell surface Fas intensity in E2 treated cultures compared to controls. (B,C,E) Quantitative analysis (mean ± SEM) of the number of cells expressing Fas (FasMod + FasHi) in control and E2 treated cultures, normalized to controls. Since these analyses were performed on adherent cells, the FasHi population was insignificant. (D) Quantitative analysis of the mean cell-surface intensity of Fas expression in control and E2 treated cultures. Asterisks indicate statistical significance at p < 0.05.

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