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Table 1 Forskolin induces pigment aggregation in a dose-dependent manner.

From: Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill

Concentration Pigment Index± SEM n
0 μM 0.98 ± 0.00 6
0.1 μM 0.93 ± 0.00 3
1 μM 0.89 ± 0.01 3
10 μM 0.75 ± 0.02 2
100 μM 0.71 1
  1. RPE was isolated from dark-adapted bluegill and incubated 45 minutes in increasing concentrations of forskolin. Tissue fixed prior to incubation in forskolin had a pigment index of 0.97 ± 0.00 (n = 6 fish). Maximal aggregation was attained by concentrations as low as 10 μM.