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Figure 5 | BMC Neuroscience

Figure 5

From: Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK

Figure 5

The killing effect of TM Foxo3a involves the JNK pathway.Motoneurons were electroporated with HA-wt-Foxo3a and cultured for 2 d with NTFs in the presence or not of a JNK inhibitor, L-JNKl1 (1 μM). Blocking the JNK pathway in motoneuron reduces the killing effect of TM-Foxo3a by about 20 %. Results are mean ± SD of 6 wells in 3 independent experiments. The 100 % corresponds to the number of motoneurons electroporated with HA-wt-Foxo3a and untreated. Differences with the TM-Foxo3a effect in L-JNKl1-treated compared with control neurons were found significant using Student's t-test (p < 0.001).

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