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Table 2 Lamina cribrosa cell and ONH astrocyte responses to oxygen-glucose deprivation.

From: Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation

 

Lamina cribrosa cells

ONH astrocytes

Cell Number

95 % survival at 24 hrs, 85% at 48 hrs

70 % survival at 24 hrs, 80% at 48 hrs

NT Expression

↑ NGF, ↑ BDNF, ↑ NT-3; ↓ NT-4

↑ BDNF, ↑ NT-3; ↓ NGF, ↓ NT-4

Trk Expression

↑ Trk A; ↓ Trk C, ↓ Trk B

↓ Trk A, ↓ Trk C, ↓ Trk B.T

Phospho-Trk Expression

↑ 120 kDa isoform (Trk A); ↓ 148 kDa isoform

↓ all phospho-trk receptors

 

isoform

 

Secretion of NTs

↑ NGF; ↓ BDNF

↑ NGF; ↓ BDNF