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Table 1 GABA antagonist effects on anesthetic-induced depression of population spike responses

From: Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices

Anesthetic

Percent reversal of anesthetic-induced depression

 

Bicuculline

Pictrotoxin

CGP-GABAB

Propofol

69.5 ± 14.3 %

72.3 ± 8.2 %

3.1 ± 4.1%

Thiopental

64.9 ± 12.9 %

68.3 ± 9.7 %

1.3 ± 3.0%

Pentobarbital

56.2 ± 12.4 %

54.3 ± 11. 5%

0.8 ± 6.3 %

Halothane

22.3 ± 18.4 %

20.8 ± 15.3 %

0.5 ± 3.3 %

Isoflurane

16.2 ± 7.4 %

19.5 ± 10.2 %

3.4 ± 4.8 %

  1. Notes: Bicuculline effects on propofol, thiopental and pentobarbital p < 0.01
  2. Bicuculline effects on halothane and isoflurane p < 0.1
  3. Picrotoxin effects on propofol, thiopental and pentobarbital p < 0.01
  4. Picrotoxin effects on halothane and isoflurane p < 0.1
  5. CGP effects were not significant for any anesthetic studied.