Figure 6

Brevican immunoreactivity in the dentate gyrus after entorhinal cortex lesion: Brevican immunoreactivity in the contralateral (CL) and ipsilateral (IL) dentate gyrus of mice that had undergone ECL two, seven, and thirty days earlier. Optical density was measured on the Western blots and data from the ipsilateral side was expressed as a fraction of the contralateral dentate. A: At two days, the CS-containing, >145 kD brevican was significantly elevated on the lesion side compared to the contralateral side although all fragments showed a trend for increase. B: At seven days, there was a significant elevation of the ADAMTS-derived EAMESE fragment of brevican and a trend for an increase in 55 kD fragment. C: At thirty days, brevican isoforms were not different from the control side, except that the >145 kD core protein was slightly elevated.