Figure 10
Anterograde degeneration of transected WldS axons initially involves proximal axonal atrophy with occasional interruptions. Confocal composite picture showing eight consecutive lengths (from top to bottom in overview) of the proximo-distal course of an individual YFP labelled WldS axon within a peripheral triple heterozygote nerve stump 15 days after transection injury displaying an anterograde progression of axon degeneration. Note that this axon shows predominantly narrowings (red asterisks) and occasionally interruptions (white arrows) in its most proximal end (inset 1) with a gradual decrease of this degeneration signs over a few millimetres more distal (inset 2) while at its distal parts almost no degeneration can be identified (inset 3 and 4). YFP fluorescence has been pseudo-coloured yellow with the applied confocal imaging software (Biorad LaserSharp 2000). Scale bar: 500 μm