Figure 4

Effects of SL327 on the induction and expression of locomotor sensitization by repeated administration of cocaine. A) Locomotor responses measured during 5 consecutive days after administration of cocaine (20 mg/kg, i.p.) 30 min after pre-treatment with vehicle (Veh) or SL327 (30 mg/kg), as indicated (10 mice per group). After 10 days of withdrawal (day 15), the Veh/cocaine and SL327/cocaine groups received an additional treatment with Veh/cocaine and SL327/cocaine, respectively. B) Locomotor responses measured during 5 consecutive days after administration of saline 30 min after pre-treatment with vehicle (Veh) or SL327 (30 mg/kg), as indicated (10 mice per group). After 10 days of withdrawal (day 15), the Veh/saline and SL327/saline groups received an additional treatment with Veh/cocaine. Data were analyzed with a mixed factor ANOVA (repeated measure over time): for saline group (effect of time: F_(4,90) = 1.66, NS; effect of SL327: F_(1,90) = 1.29, NS); for cocaine group (effect of time: F_(6,126) = 11.27, P < 0.01; effect of SL327: F_(1,126) = 18.27, P < 0.01). Bonferroni test: * P < 0.01 compared to day 1, ° P < 0.01 Veh/D-amph vs SL327/D-amph.