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Figure 5 | BMC Neuroscience

Figure 5

From: Role of the ERK pathway in psychostimulant-induced locomotor sensitization

Figure 5

Effects of SL327 on the induction of a conditioned locomotor response to saline administration. A) Locomotor responses measured during the first 30 min after injection of saline in mice which have received repeated injections of saline or D-amph, preceded by pre-treatment by vehicle (Veh) or SL327 (30 mg/kg) 30 min before (see Fig 3). Saline injection was done in the same actimeter in which the mice had received the repeated injections. B). Analysis of conditioned response in mice chronically treated with cocaine (same protocol as in A except that mice had received repeated injections of cocaine, 20 mg/kg, instead of D-amph). Data were analyzed with one-way ANOVA (A): F(3,36) = 8.235, P < 0.001; (B) F(3,36) = 8.585, P < 0.001, followed by Bonferroni test: * P < 0.05, ** P < 0.01 saline vs D-amph or cocaine; ° P < 0.01 vehicle vs SL327. 10 mice per group.

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