Skip to main content

Table 1 Effects of SL327 on ERK phosphorylation in various brain areas (% of vehicle-treated controls)

From: Role of the ERK pathway in psychostimulant-induced locomotor sensitization

Brain areas

 

Vehicle

SL327 (15 mg/kg)

SL327 (30 mg/kg)

SL327 (50 mg/kg)

F(3,12)

Dorsal Striatum

 

100 ± 18

46 ± 10**

11 ± 6***

0 ± 0***

17.61

N. Accumbens

Core

100 ± 16

62 ± 15

13 ± 8**

0 ± 0***

15.55

 

Shell

100 ± 13

65 ± 13

23 ± 12**

0 ± 0***

16.37

BNST

Lateral

100 ± 11

52 ± 5**

18 ± 7**

0 ± 0***

39.68

Amygdala

Central

100 ± 15

62 ± 11

15 ± 13**

0 ± 0***

16.15

Prefrontal Cortex

 

100 ± 10

63 ± 27

38 ± 17**

0 ± 0***

6.34

  1. The number of positive nuclei was counted as described in Materials and Methods, and expressed as % of the average of controls (data are means ± SEM, 4 mice per group). BNST: bed nucleus of the stria terminalis. ANOVA F values are indicated in the right column (for all values P < 0.01). Post-hoc comparison of Vehicle vs SL327 was done with Bonferroni test. ** P < 0.01, *** P < 0.001.