Table 3 Effects of inhibitors of caspases 3, 8 and 9 against toxicity and ROS accumulation after serum deprivation in enriched hippocampal neuronal cultures, as estimated by MTT and DCF assays, respectively.
Drugs | MTT values (% of control) | DCF values (% of control) |
|---|---|---|
Control | 100 ± 4 | 100 ± 6 |
+ Inhibitor of caspase 3 (DEVDO-CHO, 5 μM) | 171 ± 12 * | 85 ± 4 |
+ Inhibitor of caspase 8 (IETD-CHO 5 μM) | 141 ± 9 * | 96 ± 5 |
+ Inhibitor of caspase 9 (LEHD-CHO, 5 μM) | 135 ± 10 * | 89 ± 6 |
+ Clozapine (1 μM) | 140 ± 8 * | ND |