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Table 4 [3H]-QNB binding constants in cerebellar and hippocampal membranes after administration of a convulsant (7.5 mg/kg) BIC dose.

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area

Condition

Kd (pM)

Δ (%)

Bmax (pmol.mg prot-1)

NH

Cerebellum

Control

200.1 ± 7.1

 

0.35 ± 0.01

1.00 ± 0.01

 

Convulsive

133.3 ± 7.5***

- 33

0.42 ± 0.07

1.05 ± 0.02

Hippocampus

Control

108.8 ± 2.7

 

1.75 ± 0.08

1.01 ± 0.06

 

Convulsive

185.6 ± 3.9***

+ 85

1.72 ± 0.11

0.98 ± 0.02

  1. For each experiment, cerebellum and hippocampus from five rats were pooled, membranes separated and [3H]-QNB binding assayed. Data from three experiments were processed to calculate constants. Results presented are mean values ± S.D.
  2. *** P < 0.001 (Student-t test).