Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro

Table 1 DA modulation of autaptic connections. Data are organized by the receptor targeted. The Incidence data give the percent of connections that showed modulation greater than 5%; less that a 5% modulation is reported as Neither. The Magnitude data (expressed as the percentage of the preceding control response) give the average size of the inhibited or facilitated IPSC for those connections showing inhibition or facilitation, respectively. DA or the combination of the D1 agonist SKF38393 (SKF) and the D2 agonist quinpirole (Quin) targeted DA receptors as a class. SKF38393 or DA in the presences of Sulpiride (Sulp) targeted D1 receptors. Similarly, Quinpirole or DA in the presence of the D1 antagonist SCH23390 (SCH) targeted D2 receptors. The other monoamines norepinephrine (NE) and serotonin (5-HT) were also tested. n/a, not applicable.

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