Figure 2

Intra-peritoneal minocycline 45 mg/kg treatment twice a day (first dose immediately after reperfusion), significantly reduced the ischemia-induced increase in MMP-2 and MMP-9 gelatinolytic activities (represented by the active form bands; 67 and 86 kDa respectively). Sample sizes: PBS n = 6; Minocycline n = 8 (p < 0.0003). Each band represents one different replicate sample.