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Figure 4 | BMC Neuroscience

Figure 4

From: Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease

Figure 4

HDG 20 inhibits aggregation of mutant Htt fragment. HDG 20, a 20-base monotonic G oligonucleotides was tested in the assay outlined in Figure 1 (see legend) at the indicated concentration. The reaction was carried out 4 times in duplicate for 24 hours and a representative blot from the four independent experiments is shown. 0 hour, reaction mixture stopped at time zero; 24 hours, control reaction lacking oligonucleotides. (Inset), The Flow-through from filter binding reaction containing HDG 20 (20 μM or 40 μM) was placed on blotting paper, dried and processed as described in the legend to Figure 1.

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