Figure 10From: Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetricPeak optic nerve damage precedes peak retinal damage in DBA/2J mice. Line graph of the mean optic nerve degeneration (closed circles) and mean retinal degeneration (open circles) as a function of age in two cohorts of DBA/2J mice. In this comparative analysis, DBA/2J mice exhibited optic nerve disease before they exhibited retinal disease, consistent with theories of human glaucoma that predict that the initial damage in response to ocular hypertension occurs at the level of the lamina cribrosa [14, 17, 30].Back to article page